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Diphyllin O-glucoside
CAS No. 30021-77-3
Diphyllin O-glucoside ( 山荷叶素 O-葡萄糖苷 )
产品货号. M38350 CAS No. 30021-77-3
Cleistanthin B (Diphyllin O-glucoside) 是一种具有口服活性的芳基萘木酚素内酯糖苷。Cleistanthin B 在 Vero 细胞中表现出抗 SARS-CoV-2 作用，EC50 值为 6.51 μM。Cleistanthin B 在体内具有抗肿瘤、利尿和抗高血压的作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 25MG | 获取报价 | 有现货 |
|
| 50MG | 获取报价 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
生物学信息
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产品名称Diphyllin O-glucoside
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Cleistanthin B (Diphyllin O-glucoside) 是一种具有口服活性的芳基萘木酚素内酯糖苷。Cleistanthin B 在 Vero 细胞中表现出抗 SARS-CoV-2 作用，EC50 值为 6.51 μM。Cleistanthin B 在体内具有抗肿瘤、利尿和抗高血压的作用。
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产品描述Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 μM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo.
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体外实验Cleistanthin B (25-100 mg/kg; p.o. for 10 dys) has antitumor activity against EAC and DAL tumor mice but it is not effective against solid tumor.
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体内实验Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 μM.Cleistanthin B shows no cytotoxic to Vero cells in concentrations up to 100 μM.
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同义词山荷叶素 O-葡萄糖苷
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通路Others
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靶点Other Targets
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受体IC50: 6.51 μM (SARS-CoV-2)
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研究领域———
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适应症———
化学信息
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CAS Number30021-77-3
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分子量542.488
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分子式C27H26O12
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纯度>98% (HPLC)
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溶解度———
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SMILES———
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化学全称———
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Stefanik M, et, al. Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2. Microorganisms. 2021 Feb 25;9(3):471.?2. Thummar VR, et, al. Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice. J Tradit Complement Med. 2015 Sep 3;6(4):383-388.?3. Parasuraman S, et, al. Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats. J Young Pharm. 2012 Apr;4(2):73-7.?4. Priyadharsini RP, et, al. Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B. J Basic Clin Pharm. 2014 Sep;5(4):109-14.?
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